Not sure to what extent this affects, but at the very least I was unable to use Chilling Smite on an enemy Vladimir. I'm unable to provide concrete proof/replication steps of the bug, but considering Vladimir has a new skin and the enemy in question was using Academy Vladimir, the cause of the bug relating to the skin is likely.
Predicted replication steps:
1. Use Chilling Smite on enemy Vladimir using Academy skin.
2. Observe no effect, even after spamming the spell multiple times.